About FTD & Related Disorders

Frontotemporal degeneration (FTD) refers to a family of disorders characterized by the progressive loss of neurons (brain cells) in the frontal and temporal regions of the brain.

Patients with FTD can present with different clinical symptoms, ranging from behavioral impairments to language or motor dysfunction. Although the precise cause may not be known, Frontotemporal degeneration is thought to result from abnormal accumulation of misfolded proteins, which disrupt, and eventually lead to degeneration of brain cells.

As FTD progresses, it can slowly deprive an individual of their cognitive abilities, personality and eventually their independence. An estimated 10,000 individuals are diagnosed with FTD each year. Symptoms of Frontotemporal degeneration often first appear between the ages of 50 to 65 years of age.

What are these conditions

Frontotemporal degeneration (FTD) refers to a family of disorders characterized by the progressive loss of neurons (brain cells) in the frontal and temporal regions of the brain. Although the precise cause is unknown, FTD is thought to result from abnormal accumulation of misfolded proteins, which disrupt, and eventually kill brain cells.

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How do we diagnose these conditions?

As the symptoms of Frontotemporal degeneration often first appear in a person’s 50’s or 60’s and can include dramatic changes in behavior and personality, it is not unusual for an individual to be referred to multiple specialists, such as a psychiatrist, before an accurate diagnosis is made. To assess for Frontotemporal degeneration, Dr. Grossman and his clinical team will gather a detailed medical history and complete a thorough neurological examination.

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What to Expect at Your Appointment

At the initial visit, the neurologist will review previous medical records (such as physician reports or previous neuropsychological evaluations), take a history from the patient as well as the caregiver, conduct a cognitive assessment, and perform a neurologic exam.

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Making an Appointment

To schedule a clinic appointment with one of our clinicians, please call the Penn Neurology Call Center at 215-662-3606 and request a first-time appointment with Dr. Murray Grossman or Dr. David Irwin.

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About FTD & Related Disorders

Making an Appointment

To schedule a clinic appointment with one of our clinicians, please call the Penn Neurology Call Center at 215-662-3606 and request a first-time appointment with Dr. Murray Grossman or Dr. David Irwin.