Frontiers in Human Neuroscience 8:610, 2014. PMCID: PMC4124462
Quantiﬁers, like “some” or “few,” are frequent in daily language. Linguists posit at least three distinct classes of quantiﬁers: cardinal quantiﬁers that rely on numerosity, majority quantiﬁers that additionally depend on executive resources, and logical quantiﬁers that rely on perceptual attention. We used BOLD fMRI to investigate the roles of frontal and parietal regions in quantiﬁer comprehension. Participants performed a sentence-picture veriﬁcation task to determine whether a sentence containing a quantiﬁer accurately describes a picture. A whole-brain analysis identiﬁed a network involved in quantiﬁer comprehension: This implicated bilateral inferior parietal, superior parietal and dorsolateral prefrontal cortices, and right inferior frontal cortex. We then performed region-of-interest analyses to assess the relative contribution of each region for each quantiﬁer class. Inferior parietal cortex was equally activated across all quantiﬁer classes, consistent with prior studies implicating the region for quantiﬁer comprehension due in part to its role in the representation of number knowledge. Right superior parietal cortex was up-regulated in comparison to frontal regions for cardinal and logical quantiﬁers, but parietal and frontal regions were equally activated for majority quantiﬁers and each frontal region is most highly activated for majority quantiﬁers.This ﬁnding is consistent with the hypothesis that majority quantiﬁers rely on numerosity mechanisms in parietal cortex and executive mechanisms in frontal cortex. Also, right inferior frontal cortex was up-regulated for logical compared to cardinal quantiﬁers, which may be related to selection demands associated with logical quantiﬁer comprehension. We conclude that distinct components of a large-scale fronto-parietal network contribute to speciﬁc aspects of quantiﬁer comprehension, and that this biologically deﬁned network is consistent with cognitive theories of quantiﬁer meaning.
FTD Caregiver, Jamie Arking, shares the story of his father's experience with Frontotemporal degeneration (FTD).
FTD Caregiver, Sandy Karger, shares the story of her husband's experience with Frontotemporal degeneration (FTD).
FTD Caregiver, Diane Fehon, shares the story of her husband's experience with Frontotemporal degeneration (FTD).
Frontotemporal degeneration (FTD) is a debilitating neurodegenerative disease that dramatically affects the lives of both the patient and their loved ones. Hear the stories of three dedicated FTD caregivers and their experience with the Penn Frontotemporal Degeneration Center.
William Reiter of the Alzheimer’s Association Delaware Valley Chapter wrapped up the conference with a presentation on community resources.
Matthew Sharp, MSS of the Association for Frontotemporal Degeneration (AFTD) discusses the importance of FTD Advocacy.
Paul L. Feldman, a founding partner of the law firm of Feldman and Feldman, stressed that it is never too early to talk about and plan for the future.
The Penn FTD Center's Lauren Massimo, PhD, CRNP discusses decision making in advanced illness, focussing on interventions to promote quality of life
Dr. Corey McMillan discusses the importance of biomarkers.
Dr. David Irwin of the Penn FTD Center discusses how improving the ability to distinguish between FTD subtypes is crucial to both clinical treatment and research
Diane Fehon talks about her FTD caregiving journey
Murray Grossman, MD, EdD Intrdoces the premiere of Through the Eyes of the Caregiver: The Penn Frontotemporal Degeneration (FTD) Center
Alison Lynn, MSW, LSW of the Penn Memory Center discusses how the diagnosis of neurodegenerative disease in a loved one impacts children and teens.
Kaylee Faulkner Naczi, MS, CGC of the Penn Telegenetics Program educates the audience about the genetics of FTD
Dr. Roy Hamilton discusses strategies for improving Primary Progressive Aphasia
Anna Yung, BSN, RN presents practical strategies for managing symptoms at home
Dr. H. Branch Coslett from the Penn Neuroscience Center presents on Corticobasal Syndrome & Progressive Supranuclear Palsy
Dr. Colin Quinn who treats patients at the Veteran's Association and the Penn Neuroscience Center presents on Amyotrophic Lateral Sclerosis
Dr. Murray Grossman presents an overview of behavioral-variant Frontotemporal Degeneration (bvFTD) and Primary Progressive Aphasia (PPA).
Murray Grossman, MD, EdD Penn Frontotemporal Degeneration Center
Susan L-J Dickinson, MS, CGC Association for Frontotemporal Degeneration
William Reiter Alzheimer’s Association, Delaware Valley Chapter
Kathryn Jedrziewski, PhD Institute on Aging, University of Pennsylvania