Neuroimage 84: 698-711, 2014. PMCID: PMC3911786
This study establishes that sparse canonical correlation analysis (SCCAN) identifies generalizable, structural MRI-derived cortical networks that relate to five distinct categories of cognition. We obtain multivariate psychometrics from the domain-specific sub-scales of the Philadelphia Brief Assessment of Cognition (PBAC). By using a training and separate testing stage,we find that PBAC-defined cognitive domains of language, visuospatial functioning, episodic memory, executive control, and social functioning correlate with unique and distributed areas of gray matter (GM). In contrast, a parallel univariate framework fails to identify, from the training data, regions that are also significant in the left-out test dataset. The cohort includes164 patients with Alzheimer's disease, behavioral-variant frontotemporal dementia, semantic variant primary progressive aphasia, non-fluent/agrammatic primary progressive aphasia, or corticobasal syndrome. The analysis is implemented with open-source software for which we provide examples in the text. In conclusion, we show that multivariate techniques identify biologically-plausible brain regions supporting specific cognitive domains. The findings are identified in training data and confirmed in test data.
FTD Caregiver, Jamie Arking, shares the story of his father's experience with Frontotemporal degeneration (FTD).
FTD Caregiver, Sandy Karger, shares the story of her husband's experience with Frontotemporal degeneration (FTD).
FTD Caregiver, Diane Fehon, shares the story of her husband's experience with Frontotemporal degeneration (FTD).
Frontotemporal degeneration (FTD) is a debilitating neurodegenerative disease that dramatically affects the lives of both the patient and their loved ones. Hear the stories of three dedicated FTD caregivers and their experience with the Penn Frontotemporal Degeneration Center.
William Reiter of the Alzheimer’s Association Delaware Valley Chapter wrapped up the conference with a presentation on community resources.
Matthew Sharp, MSS of the Association for Frontotemporal Degeneration (AFTD) discusses the importance of FTD Advocacy.
Paul L. Feldman, a founding partner of the law firm of Feldman and Feldman, stressed that it is never too early to talk about and plan for the future.
The Penn FTD Center's Lauren Massimo, PhD, CRNP discusses decision making in advanced illness, focussing on interventions to promote quality of life
Dr. Corey McMillan discusses the importance of biomarkers.
Dr. David Irwin of the Penn FTD Center discusses how improving the ability to distinguish between FTD subtypes is crucial to both clinical treatment and research
Diane Fehon talks about her FTD caregiving journey
Murray Grossman, MD, EdD Intrdoces the premiere of Through the Eyes of the Caregiver: The Penn Frontotemporal Degeneration (FTD) Center
Alison Lynn, MSW, LSW of the Penn Memory Center discusses how the diagnosis of neurodegenerative disease in a loved one impacts children and teens.
Kaylee Faulkner Naczi, MS, CGC of the Penn Telegenetics Program educates the audience about the genetics of FTD
Dr. Roy Hamilton discusses strategies for improving Primary Progressive Aphasia
Anna Yung, BSN, RN presents practical strategies for managing symptoms at home
Dr. H. Branch Coslett from the Penn Neuroscience Center presents on Corticobasal Syndrome & Progressive Supranuclear Palsy
Dr. Colin Quinn who treats patients at the Veteran's Association and the Penn Neuroscience Center presents on Amyotrophic Lateral Sclerosis
Dr. Murray Grossman presents an overview of behavioral-variant Frontotemporal Degeneration (bvFTD) and Primary Progressive Aphasia (PPA).
Murray Grossman, MD, EdD Penn Frontotemporal Degeneration Center
Susan L-J Dickinson, MS, CGC Association for Frontotemporal Degeneration
William Reiter Alzheimer’s Association, Delaware Valley Chapter
Kathryn Jedrziewski, PhD Institute on Aging, University of Pennsylvania