Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 16:31-39, 2015. PMCID: PMC4372458
Quantitative examinations of speech production in amyotrophic lateral sclerosis (ALS) are rare. To identify language features minimally confounded by a motor disorder, we investigated linguistic and motor sources of impaired sentence expression in ALS, and we related deficits to gray matter (GM) and white matter (WM) MRI abnormalities. We analyzed a semi-structured speech sample in 26 ALS patients and 19 healthy seniors for motor- and language-related deficits. Regression analyses related grammaticality to GM atrophy and reduced WM fractional anisotropy (FA). Results demonstrated that ALS patients were impaired relative to controls on quantity of speech, speech rate, speech articulation errors, and grammaticality. Speech rate and articulation errors were related to the patients’ motor impairment, while grammatical difficulty was independent of motor difficulty. This was confirmed in subgroups without dysarthria and without executive deficits. Regressions related grammatical expression to GM atrophy in left inferior frontal and anterior temporal regions and to reduced FA in superior longitudinal and inferior frontal-occipital fasciculi. In conclusion, patients with ALS exhibit multifactorial deficits in sentence expression. They demonstrate a deficit in grammatical expression that is independent of their motor disorder. Impaired grammatical expression is related to disease in a network of brain regions associated with syntactic processing.
FTD Caregiver, Jamie Arking, shares the story of his father's experience with Frontotemporal degeneration (FTD).
FTD Caregiver, Sandy Karger, shares the story of her husband's experience with Frontotemporal degeneration (FTD).
FTD Caregiver, Diane Fehon, shares the story of her husband's experience with Frontotemporal degeneration (FTD).
Frontotemporal degeneration (FTD) is a debilitating neurodegenerative disease that dramatically affects the lives of both the patient and their loved ones. Hear the stories of three dedicated FTD caregivers and their experience with the Penn Frontotemporal Degeneration Center.
William Reiter of the Alzheimer’s Association Delaware Valley Chapter wrapped up the conference with a presentation on community resources.
Matthew Sharp, MSS of the Association for Frontotemporal Degeneration (AFTD) discusses the importance of FTD Advocacy.
Paul L. Feldman, a founding partner of the law firm of Feldman and Feldman, stressed that it is never too early to talk about and plan for the future.
The Penn FTD Center's Lauren Massimo, PhD, CRNP discusses decision making in advanced illness, focussing on interventions to promote quality of life
Dr. Corey McMillan discusses the importance of biomarkers.
Dr. David Irwin of the Penn FTD Center discusses how improving the ability to distinguish between FTD subtypes is crucial to both clinical treatment and research
Diane Fehon talks about her FTD caregiving journey
Murray Grossman, MD, EdD Intrdoces the premiere of Through the Eyes of the Caregiver: The Penn Frontotemporal Degeneration (FTD) Center
Alison Lynn, MSW, LSW of the Penn Memory Center discusses how the diagnosis of neurodegenerative disease in a loved one impacts children and teens.
Kaylee Faulkner Naczi, MS, CGC of the Penn Telegenetics Program educates the audience about the genetics of FTD
Dr. Roy Hamilton discusses strategies for improving Primary Progressive Aphasia
Anna Yung, BSN, RN presents practical strategies for managing symptoms at home
Dr. H. Branch Coslett from the Penn Neuroscience Center presents on Corticobasal Syndrome & Progressive Supranuclear Palsy
Dr. Colin Quinn who treats patients at the Veteran's Association and the Penn Neuroscience Center presents on Amyotrophic Lateral Sclerosis
Dr. Murray Grossman presents an overview of behavioral-variant Frontotemporal Degeneration (bvFTD) and Primary Progressive Aphasia (PPA).
Murray Grossman, MD, EdD Penn Frontotemporal Degeneration Center
Susan L-J Dickinson, MS, CGC Association for Frontotemporal Degeneration
William Reiter Alzheimer’s Association, Delaware Valley Chapter
Kathryn Jedrziewski, PhD Institute on Aging, University of Pennsylvania